Bacterial cyanogenesis occurs in the cystic fibrosis lung

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Bacterial cyanogenesis occurs in the cystic fibrosis lung.

The cystic fibrosis (CF) lung environment is poorly defined, but data suggest that bacteria may encounter reduced oxygen tensions and possibly an anaerobic environment. Pseudomonas aeruginosa produces the potent toxin cyanide under strictly microaerobic conditions. Evidence of bacterial cyanogenesis in the CF lung was investigated in the present study by measuring sputum cyanide concentrations....

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Bacterial activity in cystic fibrosis lung infections

BACKGROUND Chronic lung infections are the primary cause of morbidity and mortality in Cystic Fibrosis (CF) patients. Recent molecular biological based studies have identified a surprisingly wide range of hitherto unreported bacterial species in the lungs of CF patients. The aim of this study was to determine whether the species present were active and, as such, worthy of further investigation ...

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ژورنال

عنوان ژورنال: European Respiratory Journal

سال: 2008

ISSN: 0903-1936,1399-3003

DOI: 10.1183/09031936.00152407